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Description

Glucagon-like peptide 1 therapy: from discovery to type 2 diabetes and beyond

LH: conceptualization, writing - original draft, and writing - review and editing

This binding transcriptionally upregulates the expression of a series of key genes, including GCLC, GCLM (the light chain of GCLC), and xCT (system xc, responsible for cysteine uptake), thereby increasing GSH synthesis and cysteine uptake, thereby strengthening the cell's antioxidant defenses