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Inhibiting melanin production to reduce the appearance of new pigmentation

In the SURMOUNT-1 trial, people treated with tirzepatide lost up to 22.5% of their body weight over 72 weeks , making it even more effective than semaglutide (NEJM tirzepatide study)

It works similarly to allopurinol in that it inhibits xanthine oxidase, a key enzyme in the pathway that produces uric acid, and thereby reduces total body uric acid level

We supposed that Nrf2-mediated biosynthesis of GSH is impaired by the stimulation of CS, whereas GHK-Cu modulates Nrf2, attenuates pulmonary oxidative stress and thereby restores GSH depleted by CS