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Poor methylation can also lead to high homocysteine and several cardiovascular diseases

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In response to cold exposure, beta-adrenergic stimulation, or exercise, WAT can undergo phenotypic switching (browning) into beige adipose tissues that, though arising from distinct developmental origins from BAT [37], are similar to BAT in morphological features as well as in pro-lipolytic, anti-inflammatory, and UCP1-mediated thermogenic properties [38,39,40,41]

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