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The article highlights how inflammatory mediators influence brain regions implicated in mood regulation, such as the hippocampus, amygdala, and prefrontal cortex
[6] Folinic acid was first made in 1945
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However, in OA, chronic inflammation and oxidative stress often dysregulate lipid metabolism, leading to increased synthesis and accumulation of n-6 PUFAs such as arachidonic acid and linoleic acid
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