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These differences manifest in sexbiased neurodegeneration pathologiespostmenopausal females show 2fold higher Alzheimer's incidence (linked to estrogen loss and APOE4tau interactions), whereas males have 1.5fold greater Parkinson's risk (associated with iron accumulation in substantia nigra) [156]

Progressive rash despite supportive care, blistering lesions, facial or airway swelling, or suspected severe cutaneous adverse reactions demand urgent intervention

( E ) DPP4 activity