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There is no evidence that NRT is harmful in pregnancy and licensed NRT medication is routinely used to aid cessation While patients may be prescribed varenicline or bupropion, the drug of choice is most likely to be varenicline unless there are medical contra-indications [footnote 53]

Research published in the PMC (PubMed Central) database of the National Institutes of Health identifies cigarette smoking as a major risk factor for gastrointestinal disorders, including peptic ulcer, Crohn's disease, and several cancers

However, AZA treatment promoted the Bcl-2 promoter demethylation, increased the expression of Bcl-2 and decreased the apoptosis index