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This integrative strategy improves the chances that a candidate natural drug will have reproducible, mechanism-based effects even with multiple molecular targets, thereby facilitating its progression through the drug development pipeline

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It allows qualifying APRNs, including NPs, to hold a single multistate license valid in all compact member states, reducing the burden of individual state licensing applications

Primary outcome: Percentage change in body weight and the proportion of participants who lost at least 5% of baseline weight by week 68 Results: Primary outcome (% weight loss): Wegovy - 16%, Placebo - 5.7% (p 35 - 68.9% Randomized treatment groups Group 1 (374 patients): Tirzepatide titrated to the maximum tolerated dose of 10 mg or 15 mg once weekly Group 2 (376 patients): Semaglutide titrated to the maximum tolerated dose of 1.7 mg or 2.4 mg once weekly Tirzepatide was initiated at a dose of 2.5 mg once weekly, and the dose was increased by 2.5 mg every 4 weeks until a maximum tolerated dose of 10 mg or 15 mg was reached