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Pre-treatment with allopurinol (a xanthine oxidase inhibitor) or dimethyl sulfoxide (DMSO) (a hydroxyl free radical scavenger) can block the apoptotic activity induced by smoking, and does not affect the p53 level of the mucosa (26), suggesting that the apoptosis induced by cigarette smoking is mediated through reactive oxygen species (ROS) and occurs independently of the p53 pathway

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Aggressive public education about smoking as a risk factor for poor outcomes of COVID-19 could provide a cue to action, increasing interest in quitting and discouraging stress-induced increases in tobacco use

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