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Furthermore, PG and VG do not cross the airway membranes and, when inhaled in large amounts, can induce hyperosmotic stress which may further induce both proinflammatory responses as well as cell stress responses [64], [65]

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23, 2021, the agency authorized the marketing of VLN King and VLN Menthol King combusted, filtered cigarettes as modified risk tobacco products (MRTPs), which help reduce exposure to, and consumption of, nicotine for smokers who use them