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Similar trends were observed in a mouse model of pancreatic ductal adenocarcinoma (PDAC) ( LSL-Kras G12D/+ Trp53 f/f Pdx1 cre (KP / C) mice 28 ) and in humans with renal cell carcinoma 29 (Extended Data Fig

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Fat Loss and Nutrient Partitioning IGF-1 enhances glucose and amino acid uptake in muscle cells, leading to improved nutrient partitioning where calories are directed toward muscle repair rather than fat storage