Estrogens: Endogenous, Hormone-Based Therapies, and Estrogen-Like Molecules Figure 1 summarizes main molecules and compounds with estrogenic activity, including endogenous estrogens, hormone-based therapies, and estrogen-like molecules
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They are used to: Improve glycemic management in people with diabetes Support weight loss in individuals with overweight or obesity Reduce cardiovascular risk in certain patient populations Most recently, to treat moderate to severe obstructive sleep apnea These medications are typically prescribed at FDA-approved doses and titrated gradually to manage gastrointestinal side effects like nausea, diarrhea, and upset stomach
Big bets on new molecules / combinations: Investors are committing large rounds to next-gen GLP-1, GLP-1/GIP combos, amylin analogs, and oral formulations