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2013;19(1):76 to 83

Additionally, NSAIDs might be more effectively prescribed going forward, with NRF2-activating NSAIDs and non-NRF2-activating NSAIDs applied to the diseases theyre most likely to treat

(1) The quaternary ammonium structure of ipratropium carries a positive charge, limiting its systemic absorption and preventing significant penetration into the central nervous system, thereby confining its effects primarily to the pulmonary system

[7] It should not be used in individuals with hormone-sensitive tumors, such as prostate cancer or breast cancer, due to the risk of stimulating tumor growth through increased androgen or estrogen production