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As the respective macrocycles were selected as peptidemRNA fusions via a carboxy-terminal (GS) 3 -linker, each peptides C-terminus appeared likely to tolerate not only FLAG modification but also binding to an anti-FLAG monoclonal antibody (mAb) without compromising the structure of the active macrocyclic region
An 8-week randomized double-blind trial comparing GHK-Cu in nano-lipid carrier against Matrixyl 3000 showed 55.8% reduction in wrinkle volume versus control and 31.6% reduction versus the active comparator
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