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3.2 Hormonal modulation and estrogen receptor interactions Hormonal modulation and ER interactions is perhaps the most extensively investigated mechanistic axis through which natural supplement act on breast cancer biology considering estrogen signalling being the main agent for carcinogenesis, progression and therapeutic resistance especially in HR positive subtypes that comprise almost 70% of total breast cancer patients worldwide (184)

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Proceedings of the National Academy of Sciences of the United States of America 103, 15091-15096CrossRefGoogle ScholarPubMed 145van Muiswinkel, F.L., de Vos, RA., Bol, J.G

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