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Of note, naltrexone has been shown to reduce smoking urge at breath alcohol concentrations associated with heavier (i.e., 0.06) but not lighter (i.e., 0.02 to 0.04) drinking (Ray et al., 2007), which could explain why naltrexone decreased urge to smoke and increased quit rates relative to placebo among HDS but not moderate-to-light or nondrinking smokers in the present study

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This can cause parts of the leaf to be black from the process

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