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Raw counts from RNA-Seq were processed in Bioconductor package EdgeR 60 and SLEUTH 61 , the variance was estimated, and the size factor was normalised using the trimmed mean of M -values (TMM)

Activated p53 translocate to the nucleus, where it upregulates pro-apoptotic genes such as Bax, PUMA, and NOXA, while suppressing anti-apoptotic Bcl-2 expression (77)

In linea generale la carnitina viene ritenuta una molecola sicura in quanto la DL50 stata stabilita nel modello animale a 19200 mg/kg, dose assolutamente lontana da quelle comunemente utilizzate

Los mecanismos que explican la reduccin de episodios cardiovasculares observados con semaglutida, tirzepatida y posiblemente con las nuevas molculas arGLP-1 dependen, en parte, de la reduccin de peso que se acompaa de una conocida reduccin en los principales factores de riesgo cardiovascular como se ha comentado, y potencialmente, de una mejora de la disfuncionalidad del tejido adiposo