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Smokers absorb only a fraction of the nicotine content from cigarettes, referred to as nicotine yield, which is affected by factors such as the cigarettes design and the smokers behavior

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Cost simulations showed participation probabilities remained above 55% with a cost of up to 5% of a cigarettes price in Japan, and above 80% with a cost of up to 10% in Indonesia

To date, there is no available evidence to suggest that e-cigarette use is associated with clinical cardiovascular outcomes such as coronary heart disease, stroke, peripheral artery disease, and early stages of atherosclerosis