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Therefore, an even greater weight loss effect may be seen with either of these medications if supplemented with a calorie-restricted diet and regular exercise (~150 minutes/week)

Furthermore, recent investigations reported that empaglifozin is able to restore ion hemostasis in failing cardiac myocytes, reducing intracellular sodium overload by the inhibition of the sarcolemmal Na+/H+ exchanger (Packer, 2019)

Lilly has reported strong Phase 3 results, including 28.3% average weight loss over 80 weeks at the highest studied dose in one obesity trial, but the drug still requires regulatory review

While they look similar structurally, they hit completely different receptors