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Adverse Reactions in Adults with Primary Hypercholesterolemia The data described below reflect exposure to REPATHA in 8 placebo-controlled trials that included 2651 patients treated with REPATHA, including 557 exposed for 6 months and 515 exposed for 1 year (median treatment duration of 12 weeks)

Unstable or Difficult Substrates Electrophilic compounds can hydrolyze, polymerize, rearrange, or show low solubility under otherwise mild conjugation conditions

Results become visible in about six weeks, with optimal outcomes seen at the 12-week mark