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Two case reports assessing CBD (oral dosing from 600 mg/day to 1200 mg/day for 24 days) in patients with mania associated with bipolar disorder did not report any symptom improvement during monotherapy phases (although one patient demonstrated some improvement while on concurrent olanzapine and CBD) [72]

The litigation targeted the big cigarette-manufacturing companies, dubbed big tobacco by their opponents, in an effort to focus the debate on a small number of corporate actors rather than the much larger set of people involved in growing tobacco

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