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As expected, liver fibrosis indices (the APRI and FIB4 scores), which were normal at baseline, did not change significantly as an effect of therapy (see Table 3 )

Despite the fact that the receptorPI3KAKT signalling pathway originates at the plasma membrane, RHEB signalling to mTORC1 occurs exclusively on the cytosolic face of lysosomes 3

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Nucleic Acids Res 28:235242 Pettersen EF, Goddard TD, Huang CC, Couch GS, Greenblatt DM, Meng EC, Ferrin TE (2004) UCSF ChimeraA visualization system for exploratory research and analysis