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When assessing luteolin treatment after HDM sensitization, frequency of nose scratching and sneezing, and percentage of CD4+IL-4+ cells in splenocytes were reduced (Figure 7D) [162]

At 6 weeks post-TAC surgery, echocardiography analyses of these mice revealed that TAC-operated animals exhibited significant reductions in EF and FS relative to sham control mice, whereas IVSd, LVIDd and LVIDs were increased, while PQQ treatment partially reversed this TAC-induced cardiac dysfunction (Figures 1BE)

This directly impacts the NAD+/NADH ratio, a fundamental determinant of cellular energy status and metabolic flexibility