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Artesunate (ART), an artemisinin derivative, overcomes sunitinib resistance in renal cancer, with ferroptosis observed specifically in KTCTL-26 cells via ROS burst, metabolic rewiring, and p53 induction, suggesting p53 as a potential biomarker for ART responsiveness (235, 236)

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Most patients begin semaglutide at 0.25 mg once weekly, then increase by 0.25 mg increments every 714 days

SIRT5 functions as a global regulator of mitochondrial lysine succinylation and involved in metabolic regulation [124]