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SGLT2-i Initiation and Insulin De-Escalation In a retrospective cohort study by Champion et al., initiation of SGLT2-ioften in combination with metformin and/or a GLP-1 receptor agonistled to significant reductions in both insulin dose and overbasalization rates

Exploratory endpoints included the use of rescue orforglipron for weight regain of 50% or greater of the body weight reduction achieved during SURMOUNT-5, changes in patient-reported outcomes and changes in cardiometabolic parameters

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The effect of L-carnitine on fat oxidation, protein turnover