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Cancer Res 68:84738481 Guo J, Kim D, Gao J, Kurtyka C, Chen H, Yu C, Wu D, Mittal A, Beg AA, Chellappan SP, Haura EB, Cheng JQ (2013) IKBKE is induced by STAT3 and tobacco carcinogen and determines chemosensitivity in non-small cell lung cancer

Several detrimental consequences of chronic exposure have been reported, including ocular surface malignancies, alteration in tear film stability and quality, tear production and corneal epithelial thickness, loss of upper and lower eyelid meibomian glands, and dry eye symptoms or ocular irritation