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In lab-grown skin models, this translated to younger, healthier, and stronger skin

Oxidative gene reprogramming ERRs activate hundreds of target genes: mitochondrial biogenesis (NRF1, TFAM), oxidative phosphorylation (complex I, II, III, IV, V subunits), fatty acid beta-oxidation (CPT1B, MCAD, LCAD), Krebs cycle (IDH3, SDHA), type I fiber specification (myoglobin, Myh7, slow troponins), angiogenesis (VEGF-A)

As a result, the findings of this NMA provide additional evidence for the current guideline recommendation to favor GLP-1RA over TZD in obese patients with NAFLD or NASH