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Gut microbiota and lipopolysaccharide content of the diet influence development of regulatory t cells: studies in germ-free mice
doi: 10.1016/S0140-6736(04)17025-6 106 HanselTTKharitonovSADonnellyLEErinEMCurrieMGMooreWMet al
It is believed that increased immune activation induced by CTLA-4 blockade may trigger a compensatory response that leads to an increased IDO expression, further contributing to immune exhaustion (234)
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