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Impressive A1c Lowering from Once-Weekly Semaglutide in Type 2 Diabetes By Emma Ryan A recent trial comparing once-weekly GLP-1 agonists semaglutide and Trulicity found improved A1c and double the weight loss with semaglutide We recently heard about results from the SUSTAIN 7 trial of semaglutide, a powerful once-weekly, injectable GLP-1 agonist that is currently under FDA review for type 2 diabetes