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Most studies have examined its effectiveness in combination with intense counseling in depressed patients.[13] Varenicline (Champix) is considered the most effective smoking cessation aid and works by facilitating dopamine release and maintaining partial stimulation of the alpha-4 beta-2 nicotinic acetylcholine receptors.[12,14] In a study of patients with stable cardiovascular disease, varenicline use was shown to be effective and resulted in a nonsignificant decrease in death from all causes

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