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2.6.1 Nrf2 signaling Nrf2 is a crucial transcription factor that plays a significant role in preserving mucosal balance by inhibiting the excessive production of ROS in IBD.Nrf2 has a dampening effect on the inflammatory response and the damage to the mucosal lining through its antioxidant actions (87)

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As a coenzyme of specific enzymes, glutathione has the functions of scavenging free radicals, modifying proteins, protecting proteins and enzymes containing sulfhydryl groups in cell membranes from oxidation, catalyzing disulfide bond exchange reactions, and signal transduction

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