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The tobacco used to make cigarettes contains nicotine, which acts as a nerve stimulant but also causes addiction

Pont, MD, MPH, FAAP Laura Turner Seydel Jesse Sixkiller Mike Pertschuk Advisors & Ambassadors Scientific Advisory Council Louise Turner Chawla, PhD Professor Emerita, College of Architecture and Planning, University of Colorado Ming Kuo, PhD Associate Professor, Department of Natural Resources and Environmental Sciences, University of Illinois Urbana Champaign Stephen J

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Historians have found evidence of cotton in the Indus Valley of India (Pakistan today) dating back to 3000 BCE