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In general, when hyperglycaemia is corrected in individuals with type 2 diabetes using a variety of interventions, including sulfonylureas and insulin, GIP sensitivity can be restored [32, 33]

For instance, peptides TWLPLPR, KVPPLLY, and YVLLPSPK from walnut protein minimized ROS production and elevated glutathione peroxidase activity (Zhao et al., 2020)

They're expensive, he says, and in some cases, not covered by insurance when used exclusively for weight loss

Additionally, if gastrointestinal side effects persist beyond the first 8-12 weeks of treatment or worsen over time rather than improving, discuss this with your provider, as it may indicate the need for alternative treatment approaches