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Electrolytes including sodium, potassium, and chloride support nerve conduction, muscle contraction, and cardiovascular function
Jacobsen DW, Gatautis VJ, Green R, Robinson K, Savon SR, Secic M, Ji J, Otto JM, and Taylor LM Jr (1994)
The mechanisms through which these phytochemicals exert their effects include the inhibition of the MAPK/NF-B signaling pathway (notably by (2 S ,7S)- O -(2-methylbutanoyl)-columbianetin, tussilagone, platycodin D, skullcapflavone II, and diosmetin), the inhibition of IB and COX-2 signaling pathways (as seen with resveratrol and -glucan), the suppression of the STAT6/SOCS1 and GATA3/T-bet signaling pathways (mediated by morin), and the inhibition of the TLR4/MyD88/NF-B signaling pathway (as demonstrated by apigenin)
The analysis integrates findings from preclinical investigations, limited clinical data, and regulatory perspectives
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