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22 For example, oxygen levels within the TME can vary due to increased metabolic demand from rapidly proliferating tumor cells, resulting in low oxygen tension, known as hypoxia, in tissues

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In an LPS-induced inflammatory response model using intestinal epithelial cell-6, catalpol mitigates inflammation by activating the AMPK/mTOR signaling pathway, reducing the release of inflammatory factors, alleviating cellular oxidative stress, and inhibiting cell apoptosis (Gao et al., 2023)