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Common physical reactions include: Cardiovascular changes : rapid or irregular heartbeat, blood pressure fluctuations, and lightheadedness Gastrointestinal distress : nausea, vomiting, and severe headaches resembling migraines Neurological symptoms : tremors, blurred vision, and slurred speech Motor impairment : muscle weakness and compromised coordination Cognitive disruption : wellbutrin alcohol blackouts and memory lapses These effects stem from both substances simultaneously affecting neurotransmitter activity