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The molecule retains the complete 70-amino-acid native IGF-1 sequence with two structural modifications a 13-amino-acid N-terminal extension (the Long designation) and an arginine-for-glutamic-acid substitution at position 3 (the R3 designation) which together reduce binding affinity to circulating IGF binding proteins (IGFBPs) by approximately 600-fold while preserving full agonist activity at the IGF-1 receptor

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14.4 BYDUREON Glycemic Control Trials in Adults with Type 2 Diabetes Mellitus - Combination Therapy BYDUREON, another exenatide extended-release product, has been studied in combination with metformin, sulfonylurea, thiazolidinedione, sodium-glucose cotransporter-2 (SGLT2) inhibitor and basal insulin in adult patients with type 2 diabetes mellitus

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