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The NADPH oxidase (Nox) system is a major source of intracellular ROS production in the adult brain and the nicotine withdrawal induced activation of the Nox isoform-Nox-2 expression in microglia, which is believed to be the primary mechanism that results in increased ROS generation and pro-inflammatory response to nicotine withdrawal (131, 132)

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I have emailed Guerlain to see if there is anything that can be done about this because I bought from them directly