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Instead of modelling risk with consumption for each study (which is non-linear), we modelled the logarithm of risk, using similar methods as before.1214 This involved fitting a log-linear variance weighted regression model between incidence or relative risk and cigarette consumption (using all reported smoking categories in the publications)

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Sample preparation and sample analysis methods can impact the chemicals and LOD/LOQ values that are detected in studies, which may cause differences in reporting