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These findings imply that emodin protects hepatocytes from APAP-induced liver damage by activating Nrf2-mediated antioxidant stress pathways, inhibiting the NLRP3 inflammasome, and downregulating the cGAS-STING signaling pathway (Shen et al., 2022)

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The CREDENCE trial enrolled 4,401 participants with type 2 diabetes mellitus and CKD, with a mean eGFR of 56.2 mL/min/1.73 m 2 and a median urinary albumin-to-creatinine ratio (UACR) of 927 mg/g (Table 1, Fig

The RCTs were based across 12 countries on four continents, but involved only high- or middle-income countries, mostly Western