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doi:10.1155/2015/648108 Sakuma S, Ishimura M, Yuba Y, Itoh Y, Fujimoto Y
Aunque las clulas madre pueden renovarse infinitamente, su capacidad de multiplicarse disminuye con la edad
In addition, pharmacokinetic properties such as drug-likeness, gastrointestinal absorption, and blood brain-barrier (BBB) permeability are important to consider when evaluating its ADME profile ( Curcumin exhibits limited bioavailability due to poor gastrointestinal absorption, extensive first-pass metabolism, and rapid systemic clearance
After 2h shaking at 30C, cells were harvested and underwent two centrifugation steps at 1,500 g for 3 min at room temperature, followed by resuspension in isosmotic buffer to a final concentration of 1.5 OD600 units/ml
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