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d , Cell viability of HT1080 GPX4 KO /FSP1 OE cells non-target control (NT), SLC52A2 KO single clone 1 (C1) and SLC52A2 KO C1 cells stably overexpressing an empty vector (mock) or SLC52A2 (addback)

Liquid volume misread: make sure youre entering millilitres, not units

( e ) FT282-CCNE1 cells transduced with shRNA targeting CrAT, CrOT, or TMLHE (shTMLHE) were incubated with 13 C 6 -glucose, and glucose-derived M + 2 acetyl-CoA was assessed (n = 8 technical replicates representative from 2 independent experiments)

In a system that has defaulted to glucose, that surfaces as regained fat-burning: in aged mice stuck on carbohydrate, MOTS-c brought fuel use back toward fat, and treated cells could survive on lipids without glucose