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( a - d ) Observed mean percentage change from baseline over time for participants in the full analysis set during the in-trial observation period in waist circumference (a), systolic blood pressure (b), diastolic blood pressure (c), and HbA 1c (d)

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Clinical trials show tirzepatide produces up to 15% body weight reduction compared to semaglutide's typical 10-12%, with superior A1C reductions averaging 2.0-2.3% versus 1.5-1.8%