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Long time users may experience side effects that damage the body and mind, including: Inability to control impulses Concentration issues Trouble with daily functions Depression and anxiety Anger problems Sleep problems Psychosis Delusions Dangerous weight loss Gum disease Missing teeth Tooth decay Skin sores Organ damage Heart failure Not only will long-term (and short-term) meth use damage your body and mind, but you may also experience other damaging effects such as the loss of financial control, homelessness, and the loss of relationships