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This cytoprotective effect involves upregulation of antioxidant defense systems and stabilization of mitochondrial function, with Dihexa-treated cells maintaining healthier mitochondrial membrane potentials under stress conditions

In 2006 [45], it was demonstrated that chronic DIP supplementation increased glutamine concentrations in the gastrocnemius and soleus muscles immediately after an exhaustion test, compared to chronic glutamine supplementation

However, the A42/A40 ratio was not different between the two iN types (Fig

This centrality is underscored by the heart's exceptional dependence on mitochondrial oxidative phosphorylation, which supplies approximately 95% of the ATP required for contraction [23]