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The studies indicated minor complications in 3.5 to 11% of cases, with major complications occurring in less than 2% of cases, graded following the guidelines of the Society of Interventional Radiology

It is essential for protecting cells against oxidative stress and damage caused by free radicals

22,23,24,25,26,27,28 This review straightens out the circuit and physical role of lactate, sorts out the molecular mechanisms of lactate in tumor progression, and describes lactate-targeted strategies of tumor treatment, which strengthens and specifies the potent implementations of lactate in clinical applications and prognosis improvement (Fig

specific tendinopathy), validated biomarkers and functional outcomes, long term safety and immunogenicity surveillance, and pharmacovigilance for angiogenesis related adverse events