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an early phase 1b study reported that co-administration was feasible and that each components pharmacokinetics were not meaningfully altered by the other, which motivated the phase 3 program [3]

On caractrisera la phospholipase A(1) (EC 3.1.1.32) qui gnre des lysolcithines par hydrolyse spcifique du groupement acyl en position sn1, la phospholipase A(2) (EC 3.1.1.4) qui hydrolyse le groupement acyl en position sn2 en librant du 1-acylglycrophosphocholine