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176,177,178 Notably, in individuals of European ancestry, the genetic control of SLC2A9a and SLC2A9b isoforms, situated at basolateral and apical membranes respectively, constitutes a prominent genetic signal

Nicotine dependence or addiction is not just habitual but involves neurochemical changes that make cessation challenging even with a strong desire to quit, according to Neal L Benowitz in their research paper Nicotine Addiction. The high rate of dependency indicates why tobacco addiction is a critical public health concern

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