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When clinically appropriate, GLP-1 therapy can help lower cardiometabolic strain and inflammatory burden while complementing, not replacing, lifestyle fundamentals such as nutrient-dense eating, regular movement, resistance training, adequate protein intake, and restorative sleep

Preclinical research published in The Lancet demonstrated that tirzepatide attenuated dopamine reward signaling and suppressed alcohol drinking and relapse-like behaviors in rodent models

Is it some combination of all three

Clinical trials included patients with BMI 27 kg/m with comorbidities or BMI 30 kg/m, and efficacy was demonstrated across this spectrum