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Downstream, the PINK1PRKN ubiquitylation program recruits OPTN/NDP52 and activates TBK1 to execute mitophagy 17

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MtDNA gene expression and methylation does not change in airway epithelial cells after short-term (24 h) CSE exposure To study whether mitochondrial gene expression changes were induced as an immediate response to high dose CSE (higher than 10%) and whether these were related to mtDNA methylation changes, BEAS-2B cells were exposed for 24 h to 10% CSE