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Reported applications include radioligand and fluorescent binding assays at CTR and AMY1 to AMY3, cAMP accumulation and other Gs-pathway readouts, receptor internalisation and regulation studies, and structural biology: Cao and colleagues (Nat Commun, 2025) reported cryo-EM structures of cagrilintide bound to calcitonin and amylin receptors with associated PDB depositions

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Methylmalonic acid and homocysteine levels provide accurate diagnosis when serum B12 falls between 200-400 picograms per milliliter (the gray zone where symptoms appear but standard tests show normal results)

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